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Stability of doxycycline in buccal films at 4 and 25 °C. Film 1 = contained doxycycline in chitosan, gelatin, povidone, glycerin and Eudragit® RS 12.5; Film 2 = contained doxycycline, β-cyclodextrin and HPMC microparticles in chitosan, gelatin, povidone, glycerin and Eudragit® RS 12.5; and Film 3 = same as in Film 2, but the manufacturing of microparticles was performed using sodium thiosulfate, MgCl2 in 2% HPMC with Eudragit® RS 12.5.
