Table 2.
Baseline demographic and clinical information a.
| Characteristics of Children Included in This Report | |
|---|---|
| Gender | |
| Male, n (%) | 48 (59.3) |
| Gestational age (weeks); n = 81 | |
| Mean (standard deviation (SD)) | 37.6 (2.9) |
| Median (min, max) | 38.4 (27.6, 41.3) |
| Preterm (Gestational age < 37 weeks) n (%) | 21 (25.9) |
| Adjusted age at examination during ZHB (months); n = 81 | |
| Mean (SD) | 9.1 (4.7) |
| Median (min, max) | 8.1 (0.9, 21.9) |
| Birth weight (grams); n = 67 | |
| Mean (SD) | 2965 (693) |
| Median (min, max) | 3120 (755–3960) |
| Clinical Findings, n (%) | |
| Confirmed Zika virus infection in mother and/or infant b | 14 (17.3) |
| Microcephaly at birth | 5 (6.2) |
| Developmental abnormalities c | 19 (23.5) |
| At risk for developmental delays (areas) d | 18 (22.2) |
| Fine motor | 8 (9.9) |
| Communication | 7 (8.6) |
| Gross motor | 6 (7.4) |
| Problem solving | 4 (4.9) |
| Social-emotional | 3 (3.7) |
| Personal-social | 3 (3.7) |
| Other neurodevelopmental abnormalities e | 5 (6.2) |
| Abnormal tone | 4 (4.9) |
| Arthrogryposis | 1 (1.2) |
| Movement abnormality | 1 (1.2) |
| Seizures | 1 (1.2) |
a Among 81 children meeting the United States Zika Pregnancy and Infant Registry (USZPIR) eligibility criteria who attended the Zika Health Brigade (ZHB) and charts could be located. USZPIR eligibility criteria included children born between 1 December 2015 and 31 March 2018 in the United States Virgin Islands, to mothers with confirmed or possible recent zika virus (ZIKV) infection as defined by (1) recent ZIKV infection detected by Zika ribonucleic acid nucleic acid amplification test (NAAT) on any maternal, placental, fetal, or infant specimen or (2) recent ZIKV or flavivirus infection detected by serologic tests of maternal, fetal, or infant specimen [14]. b Confirmed ZIKV infection was defined as either: (1) positive NAAT or (2) positive or equivocal Zika Immunoglobulin M testing and ZIKV plaque reduction neutralization test (PRNT) ≥ 10 and dengue PRNT < 10. c Developmental abnormalities were considered present if the child was either categorized during the ZHB as “at risk for developmental delay” or found to have “other neurodevelopmental abnormalities”. Groups are not mutually exclusive. d Based on results of screening using the Ages and Stages Questionnaire −3. e Based on physical examination by a pediatric neurologist.