Table 2.
MiRNA related with NK cells in tumor progression.
| MiRNA | Status | Target | MiRNA’s regulating in NK cells | Impact on tumor progression |
|---|---|---|---|---|
| MiR-20a | Elevated | RUNX1 | Inhibit the killing effect | Promote cervical cancer cells growth (65) |
| MiRNA-130a | Elevated | STAT3 | Potentiate the killing ability | Inhibit Non-small cell lung cells growth (68) |
| MiR-182 | Elevated | NKG2D NKG2A | Enhance NK cell cytotoxicity | (69) |
| MiR-24 | Elevated | Paxillin | Inhibit the killing effect | Increase tumor volume of colorectal cancer (66) |
| MiR-544 | Elevated | RUNX3 | Decrease IFN-γ secretion and the NK cell cytotoxicity | Promote liver cancer cells growth (72) |
| MiR-140-3p | Elevated | MAPK1 | Inhibit the cytotoxicity | Facilitate ovarian cancer cells growth (73) |
| MiR-1245 | Elevated | Downregulate NKG2D expression and impair NKG2D-mediated immune responses | NKG2D can promote NK cells activation to kill tumor (74) | |
| MiR-20a | Elevated | MICA | Reduce MICA expression | Decrease Colorectal cancer cells sensitive to NK cells (75) |
| MiR-519a-3p | Elevated | ULBP2 MICA | Impair NK cells killing effect | Facilitate cancer progression and evasion (76) |
| MiR-146a | Elevated | STAT1 | Reduce NK cell-mediated cytotoxicity | (70) |
| MiR-27a-5p | Elevated | CX3CR1 | Decrease the accumulation of NK cells | Reduce the damage of NK cells to tumor cells (77) |
| MiR-30c-1* | Elevated | HMBOX1 | Depress the activation of NK cells | Inhibit the development of liver cancer (78) |
| MiRNA-155 | Elevated | BRG1 | Control natural killer/T-cell lymphoma cells viability | Promote primary xenograft growth as well as tumor-associated lymphangiogenesis (79) |
| MiR-29 | Decreased | B7-H3 | Overexpression of B7-H3 reduces the cytotoxicity effect of NK cells | Promote immune escape of solid tumors (80) |
| MiR-17/20a | Elevated | Mekk2 | Enhance NK cells to recognize tumor cells | Inhibit tumor development (81) |
| MiR-186 | Elevated | MYCN | Enhance NK cell activity | Inhibit neuroblastoma growth and immune escape (82) |
| MiR-561-5p | Elevated | CX3CL1 | Decrease CX3CR1+ NK cell infiltration and function | Promote tumorigenesis and metastasis (83) |
| MiR-506 | Decreased | STAT3 | Reduce NK cells cytotoxicity | Promote hepatocellular carcinoma cells progression (84) |
| MiR-218-5p | Elevated | SHMT1 | Suppress the killing effect of NK cells | Reduce the killing effect on Lung adenocarcinoma (67) |
| miR-146b-5p | Elevated | WBSCR22 | Enhance the function NK cells | Inhibit the oxaliplatin-resistant of colorectal cancer cell (85) |
| MiR-302c MiR-520c | Decreased | MICA/B ULBP2 | Upregulate MICA/B and ULBP2 to active NK cells | Enhance the susceptibility of cancer cells to NK cells (86) |