Table 3.
Univariate and multivariate Cox regression analyses for DFS in our TMA cohort. AFP, alpha‐fetoprotein; ALB, albumin; ALT, alanine aminotransferase; AST, aspartate transaminase; CI, confidence interval; HBsAg, hepatitis B surface antigen; SNRPC, expression in tumor nucleus; TBIL, total bilirubin.
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| SNRPC (high : low) | 4.875 | 2.922–8.131 | <0.001* | 4.343 | 2.544–7.411 | <0.001* |
| Age (≤51 : >51 years) | 0.884 | 0.609–1.281 | 0.514 | |||
| Sex (male : female) | 1.429 | 0.743–2.749 | 0.285 | |||
| HBsAg (positive : negative) | 0.933 | 0.433–2.011 | 0.859 | |||
| ALB (≤35 : >35 g L−1) | 1.267 | 0.586–2.737 | 0.548 | |||
| TBIL (>17.1 : ≤17.1 μmol L−1) | 1.171 | 0.776–1.767 | 0.453 | |||
| ALT (>40 : ≤40 U L−1) | 0.945 | 0.647–1.380 | 0.769 | |||
| AST (> 45 vs ≤ 45 U L−1) | 1.075 | 0.731–1.583 | 0.713 | |||
| AFP (>400 : ≤400 ng mL−1) | 1.328 | 0.903–1.953 | 0.150 | |||
| Tumor number (multiple : solitary) | 2.273 | 1.480–3.492 | <0.001* | 1.967 | 1.274–3.038 | 0.002* |
| Tumor size (>5 : ≤5 cm) | 1.172 | 0.810–1.696 | 0.400 | |||
| Tumor encapsulation (incomplete : complete) | 0.808 | 0.637–1.023 | 0.077 | |||
| Vascular invasion (yes : no) | 1.637 | 1.084–2.474 | 0.019* | 1.233 | 0.809–1.877 | 0.330 |
| Cirrhosis (yes : no) | 0.665 | 0.447–0.989 | 0.004* | 0.885 | 0.588–1.333 | 0.560 |
| TNM stage (III : I–II) | 2.100 | 1.425–3.094 | <0.001* | 1.323 | 0.603–2.903 | 0.484 |
*
P < 0.05.