Supplementary Figure 6.

Replication stress signature in published bulk tumor cohorts of PC. The association between molecular subtype and replication stress in the (A) ICGC RNAseq (n = 94), (B) TCGA (n = 112), and (C) ICGC microarray (n = 232) cohorts. In the ICGC (P = .006), TCGA (P = .009), and ICGC microarray cohorts (P = .037), high replication stress was significantly enriched for the squamous subtype. High replication stress was defined as the top-ranking quartile in this cohort; P was calculated using the chi-square test.