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. 2021 Jun 1;40:179. doi: 10.1186/s13046-021-01979-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Exosomal miR-31-5p directly targeted SATB2. a-b Luciferase activities of WT or mut 3’UTR in A549 cells after transfection of miR-31-5p mimic or HExo. c Expression of SATB2 after transfection miR-31-5p mimic under hypoxic or normoxic conditions. d Expression of SATB2 after treatment of HExo. Scratch assays (e) and Transwell invasion assays (f) results after transfection of si-SATB2 and/or miR-31-5p inhibitor in A549 cell line. Data are represented as the mean ± SD from three independent experiments (*, P<0.05; **, P<0.01; ***, P<0.001)