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. Author manuscript; available in PMC: 2021 Jun 9.
Published in final edited form as: Nature. 2020 Dec 9;588(7838):503–508. doi: 10.1038/s41586-020-3021-2

Extended Data Figure 1: Phylogeny and alignment of steroid and related receptors.

Extended Data Figure 1:

a, Phylogeny of steroid receptors and related nuclear receptor family members. AR, androgen receptors, PR, progestorone receptors, GR, gluccocortociod receptors, MR, mineralocortocoid receptors. Sequence identifiers are in brackets. This topology corresponds to the “Chordate tree” in Extended Data Fig. S2. Scale bar, expected substitutions per site. b, Sequence alignment of the human ER and GR LBDs, with the MAP sequences of AncSR1 and AncSR2. Green, C-terminal extension. Most ERs contain additional sequence on the C-terminus that is unalignable, even among ERs.