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. 2021 May 28;30:09636897211019025. doi: 10.1177/09636897211019025

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Administration of immunosuppressants reduces the expression levels of CD45-positive leukocytes and neutrophils at the hMSC injection site. (A) Compared to the Dexa (n = 6), Tac (n = 5), and DexaTac (n = 7) groups, severe infiltration of CD45-positive leukocytes (indicated in golden yellow) is visualized from the injection site of the hMSC group (n = 7) via IHC staining. For all 4 groups (hMSC, Dexa, Tac, and DexaTac), Iba-1 microglia cells (indicated in red) are randomly dispersed at the injection site and the region surrounding the cell graft. (B) The hMSC group shows the highest infiltration of neutrophils (indicated in golden yellow) at the injection site. The expression of neutrophils is significantly reduced for the Dexa (n = 6), Tac (n = 5), and DexaTac (n = 7) groups. CD68-positive macrophages (indicated in green) are not as densely populated as neutrophils. Macrophages are identified at and the region bordering the engraftment site. Statistical significance is defined as ** P < 0.01, *** P < 0.001, **** P < 0.0001 vs. hMSC; mean ± SEM (One-way ANOVA). Scale bar = 100 µm.