Figure 7.

T cell reactivity is attenuated at the hMSC engraftment site of BALB/c nude mice. The proliferation of CD4⁺ (top row) and CD8α⁺ (bottom row) T cells at the site of hMSC injection in C57BL/6 (n = 4) and BALB/c nude mice (n = 7) is evaluated via IHC staining. Dark brown signals, indicating the presence of T cells, can be clearly identified from the representative tissue section of C57BL/6 mice stained with the CD4 antibody while positive signals are barely detectable from representative tissue sections of BALB/c nude mice. Statistical significance is defined as **P < 0.01 vs. C57BL/6 mice; mean ± SEM (t-test). Scale bar = 200 µm.