Figure 1.

Zebrafish tools to deconvolve melanoma cell states. Zebrafish represents a powerful model to tackle melanoma heterogeneity and plasticity. A parallel study of developmental lineages (left) and melanoma initiation and residual disease modeling (right) allows simultaneously screening and detailed single-cell and functional analysis of melanoma within a complex microenvironment. Examples of the individual technologies to evaluate the varied aspects of melanoma cell states, plasticity, and microenvironmental factors are presented.