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. Author manuscript; available in PMC: 2022 Apr 22.
Published in final edited form as: J Med Chem. 2021 Apr 12;64(8):4333–4358. doi: 10.1021/acs.jmedchem.0c01686

Figure 2.

Figure 2.

(A) Chemical structures of early BCL6 inhibitors 1 and 2. (B) Binding mode of compound 1 to BCL6BTB (PDB ID: 3LBZ). Compound 1 was shown in cyan and BCL6BTB monomers are shown in green and gray, respectively. The binding pocket of BCL6BTB LG includes four continuous binding sites: acid site (cyan), aromatic site (red), linker site (blue) and HDCH site (yellow). (C) Detailed binding mode of inhibitor 1 in complex with BCL6BTB. The key residues from BCL6BTB were shown as sticks. The distances of highlighted H-bond interactions were shown in angstrom (Å).