Table 3.

Hypothesis testing using log-rank test with true IPD versus with reconstructed IPD based on data points extracted using different software

	Results based			Results based on reconstructed IPD
	on true IPD			IPDfromKM			DigitizeIt			ScanIt
	HR(SE)	p-value		HR(SE)	p-value		HR(SE)	p-value		HR(SE)	p-value
Simulated curves:
1	0.47(0.12)	<0.001		0.48(0.13)	<0.001		0.47(0.12)	<0.001		0.47(0.12)	<0.001
2	0.40(0.18)	<0.001		0.40(0.18)	<0.001		0.40(0.18)	<0.001		0.40(0.18)	<0.001
3	0.70(0.12)	0.002		0.70(0.12)	0.003		0.71(0.12)	0.003		0.70(0.12)	0.002
4	1.06(0.16)	0.735		1.06(0.16)	0.727		1.05(0.16)	0.761		1.05(0.16)	0.780
5	0.76(0.13)	0.028		0.77(0.13)	0.044		0.77(0.13)	0.039		0.77(0.13)	0.037
6	0.48(0.16)	<0.001		0.48(0.16)	<0.001		0.48(0.16)	<0.001		0.48(0.16)	<0.001
Real trial example:
1	0.49(0.22)	0.068		0.48(0.41)	0.064		0.46(0.38)	0.041		0.45(0.41)	0.041
2	0.54(0.14)	0.014		0.54(0.26)	0.017		0.56(0.26)	0.020		0.53(0.26)	0.013
3	0.59(0.11)	0.005		0.58(0.19)	0.005		0.58(0.19)	0.005		0.59(0.19)	0.007
4	1.04(0.29)	0.871		1.06(0.26)	0.830		0.99(0.25)	0.959		1.03(0.26)	0.917
5	0.73(0.12)	0.040		0.72(0.15)	0.031		0.70(0.14)	0.019		0.72(0.15)	0.036

HR hazard ratio, SE standard error