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. 2021 Mar 1;113(6):1468–1481. doi: 10.1093/ajcn/nqaa422

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© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

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Flow diagram of the inclusion of participants in the analyses for (A) biomarker concentrations and (B) B-vitamin supplement use with health-related quality of life in colorectal cancer patients from the FOCUS consortium, for the cohorts with data relevant for the research question of this paper. Selections were made based on the availability of blood samples to measure biomarker concentrations and the availability of information on B-vitamin supplement use. The overlap between both data sets was 1077 participants (64%). Abbreviation: FOCUS, biomarkers related to folate-dependent 1-carbon metabolism in colorectal cancer recurrence and survival.