TABLE 3.
Results of cross-sectional linear regression analyses of B-vitamin supplement use 6 months after diagnosis and of associations of changes in B-vitamin supplement use between diagnosis and 6 months after diagnosis with health-related quality of life
| Cross-sectional analysis of B-vitamin use at 6 months (yes/no) | Analysis of changes in B-vitamin1 use | ||||
|---|---|---|---|---|---|
| Nonuse | Use at diagnosis and 6 months | Started use after diagnosis | Stopped use after diagnosis | ||
| n = 323 | n = 1173 | n = 232 | n = 91 | n = 167 | |
| β (95% CI) | β (95% CI) | β (95% CI) | β (95% CI) | ||
| Global quality of life | |||||
| Sex and age adjusted | 0.8 (−1.6, 3.2) | REF | 2.2 (−0.6, 5.0) | −3.5 (−7.7, 0.8) | −1.5 (−4.8, 1.7) |
| Fully adjusted2 | 0.6 (−2.6, 3.8) | — | 0.5 (−3.0, 4.0) | −2.4 (−7.3, 2.4) | −3.0 (−6.3, 0.2) |
| Physical functioning | |||||
| Sex and age adjusted | −1.2 (−3.5, 1.0) | REF | −0.1 (−2.7, 2.6) | −4.5 (−8.5, −0.6) | −0.6 (−3.7, 2.4) |
| Fully adjusted2 | 0.5 (−2.4, 3.5) | — | 0.6 (−2.7, 3.9) | −2.3 (−6.9, 2.2) | −1.1 (−4.2, 1.9) |
| Role functioning | |||||
| Sex and age adjusted | 0.1 (−3.5, 3.7) | REF | 1.7 (−2.5, 5.8) | −4.0 (−10.3, 2.2) | −0.4 (−5.2, 4.4) |
| Fully adjusted2 | 1.7 (−3.1, 6.4) | — | 1.6 (−3.7, 6.8) | −1.8 (−9.0, 5.4) | −2.1 (−7.0, 2.7) |
| Emotional functioning | |||||
| Sex and age adjusted | 1.3 (−1.2, 3.7) | REF | 2.9 (0.1–5.7) | −2.9 (−7.1, 1.3) | −0.3 (−3.6, 2.9) |
| Fully adjusted2 | 0.4 (−2.7, 3.5) | — | 1.4 (−2.1, 4.8) | −3.5 (−8.3, 1.2) | −0.9 (−4.1, 2.3) |
| Cognitive functioning | |||||
| Sex and age adjusted | −2.2 (−4.7, 0.2) | REF | −1.8 (−4.7, 1.0) | −5.1 (−9.4, −0.9) | −3.7 (−6.9, −0.5) |
| Fully adjusted2 | −1.6 (−4.9, 1.8) | — | −2.3 (−6.0, 1.4) | −4.2 (−9.3, 0.9) | −4.7 (−8.1, −1.3) |
| Social functioning | |||||
| Sex and age adjusted | 0.8 (−2.1, 3.7) | REF | 2.5 (−0.9, 5.9) | −3.9 (−9.0, 1.2) | −1.1 (−5.0, 2.8) |
| Fully adjusted2 | −0.1 (−3.9, 3.7) | — | 0.3 (−3.9, 4.5) | −3.3 (−9.1, 2.5) | −2.3 (−6.2, 1.6) |
| Fatigue | |||||
| Sex and age adjusted | −0.1 (−3.3, 3.0) | REF | −1.5 (−5.1, 2.1) | 5.8 (0.4–11.3) | 5.6 (1.4–9.7) |
| Fully adjusted2 | −2.1 (−6.1, 2.0) | — | −1.6 (−6.0, 2.9) | 3.0 (−3.1, 9.2) | 7.1 (2.9–11.2)3 |
B-vitamin supplement use was defined as the use of dietary supplements containing at least 1 of the B vitamins: folic acid, vitamin B2, vitamin B6, or vitamin B12.
Fully adjusted model: adjusted for sex, age, cohort (COLON, EnCoRe, ColoCare), neo-adjuvant therapy (yes/no), adjuvant therapy (yes/no), cancer stage (I, II, III), total energy intake (kcal/day), BMI (kg/m2), adherence to physical activity guidelines (yes/no), and any supplement use (yes/no).
Statistically significant after FDR adjustment for multiple testing.