TABLE 2.
Associations between dietary DHA and episodic memory composite scores in the studied population1
| Variable | Model | APOE-ε4 in the model | Estimate (95% CI) | P | R 2 |
|---|---|---|---|---|---|
| DHA | Unadjusted | — | 0.039 (−0.184, 0.261) | 0.733 | <0.001 |
| Adjusted2 | Carrier/noncarrier3 | 0.006 (−0.227, 0.239) | 0.957 | 0.021 | |
| Number of alleles4 | 0.005 (−0.228, 0.238) | 0.964 | 0.021 | ||
| Homozygote/nonhomozygote5 | −0.001 (−0.234, 0.233) | 0.997 | 0.017 | ||
| DHA × APOE-ε4 | Unadjusted | Carrier/noncarrier3 | −0.330 (−0.782, 0.123) | 0.153 | 0.002 |
| Adjusted6 | −0.381 (−0.836, 0.074) | 0.101 | 0.011 | ||
| Unadjusted | Number of alleles4 | −0.156 (−0.454, 0.142) | 0.304 | 0.010 | |
| Adjusted6 | −0.171 (−0.470, 0.127) | 0.260 | 0.025 | ||
| Unadjusted | Homozygote/nonhomozygote5 | −0.035 (−0.599, 0.530) | 0.904 | 0.004 | |
| Adjusted6 | −0.024 (−0.588, 0.540) | 0.933 | 0.017 |
1
n = 340. Data are presented for 1 g/d of DHA, obtained by multiple linear regression analyses. Episodic memory composite scores were calculated by averaging normalized age- and education-regressed scores of all subtests in the domain. ALA, α-linolenic acid.
2
Including APOE-ε4, gender, self-reported energy intake, and ALA intake as covariates.
3
Distributed into n = 218 carriers and n = 122 noncarriers.
4
Distributed into n = 122 with 0 alleles, n = 157 with 1 allele, and n = 61 with 2 alleles.
5
Distributed into n = 61 homozygotes and n = 279 nonhomozygotes.
6
Including gender, self-reported energy intake, and ALA intake as covariates.