TABLE 1.
Baseline characteristics overall and stratified by sex and weight change category1
| Sex stratified | |||||||
|---|---|---|---|---|---|---|---|
| Men (n = 972) | Women (n = 949) | ||||||
| Characteristic | Overall cohort (n = 1921) | Weight stable (n = 548) | Not weight stable (n = 424) | P | Weight stable (n = 478) | Not weight stable (n = 471) | P |
| Age, y | 61 ± 11 | 60 ± 11 | 61 ± 12 | 0.39 | 62 ± 11 | 61 ± 12 | 0.43 |
| Race | 0.017 | 0.19 | |||||
| White | 1212 (63.2) | 330 (60.2) | 293 (69.1) | 309 (64.6) | 280 (59.4) | ||
| Asian | 140 (7.3) | 38 (6.9) | 21 (4.9) | 38 (7.9) | 43 (9.1) | ||
| Hispanic | 319 (16.6) | 72 (13.1) | 54 (12.7) | 46 (9.6) | 62 (13.2) | ||
| Black | 234 (12.2) | 101 (18.4) | 55 (13.0) | 83 (17.4) | 80 (17.0) | ||
| Other or Unknown | 16 (0.7) | 7 (1.3) | 1 (0.2) | 2 (0.4) | 6 (1.3) | ||
| Site | 0.10 | 0.09 | |||||
| Colon | 1302 (67.8) | 355 (64.8) | 253 (59.7) | 361 (75.5) | 333 (70.7) | ||
| Rectum | 619 (32.2) | 193 (35.2) | 171 (40.3) | 117 (24.5) | 138 (29.3) | ||
| Stage | 0.006 | 0.55 | |||||
| I | 361 (18.8) | 126 (23.0) | 63 (14.9) | 93 (19.5) | 79 (16.8) | ||
| II | 594 (30.9) | 177 (32.3) | 147 (34.7) | 135 (28.2) | 135 (28.7) | ||
| III | 966 (50.3) | 245 (44.7) | 214 (50.5) | 250 (52.3) | 257 (54.6) | ||
| Chemotherapy | 1344 (70.0) | 361 (65.9) | 315 (74.3) | 0.005 | 317 (66.3) | 351 (74.5) | 0.006 |
| Radiation | 397 (20.7) | 125 (22.8) | 118 (27.8) | 0.07 | 59 (12.3) | 95 (20.2) | 0.001 |
| Smoking history | 0.04 | 0.003 | |||||
| Never | 921 (48.0) | 242 (44.2) | 158 (37.3) | 288 (60.2) | 233 (49.5) | ||
| Former | 756 (39.4) | 231 (42.1) | 194 (45.8) | 144 (30.1) | 187 (39.7) | ||
| Current | 241 (12.6) | 72 (13.1) | 72 (16.9) | 46 (9.6) | 51 (10.8) | ||
| Unknown | 3 (0.2) | 3 (0.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||
| Charlson Comorbidity Index | 0.15 | 0.10 | |||||
| 0 | 1220 (63.5) | 358 (65.3) | 262 (61.8) | 318 (66.5) | 282 (59.9) | ||
| 1 | 543 (28.3) | 154 (28.1) | 120 (28.3) | 122 (25.5) | 147 (31.2) | ||
| ≥2 | 158 (8.2) | 36 (6.6) | 42 (9.9) | 38 (7.9) | 42 (8.9) | ||
| Height, m | 1.69 ± 0.11 | 1.77 ± 0.07 | 1.76 ± 0.08 | 0.35 | 1.61 ± 0.07 | 1.62 ± 0.07 | 0.16 |
| Body weight, kg | 81.2 ± 20.1 | 89.1 ± 18.3 | 87.2 ± 18.8 | 0.13 | 72.5 ± 18.0 | 75.2 ± 19.8 | 0.03 |
| BMI, kg/m2 | 28.2 ± 5.9 | 28.4 ± 4.9 | 27.9 ± 5.1 | 0.16 | 27.7 ± 6.3 | 28.6 ± 7.2 | 0.06 |
| Muscle area, cm2 | 141.8 ± 37.7 | 171.9 ± 30.4 | 165.4 ± 29.8 | 0.001 | 113.9 ± 19.1 | 113.8 ± 20.4 | 0.97 |
| Sarcopenia | 702 (36.5) | 169 (30.8) | 153 (36.1) | 0.08 | 181 (37.9) | 199 (42.2) | 0.17 |
| Muscle density, HU | 39.9 ± 9.9 | 42.0 ± 9.2 | 40.5 ± 9.5 | 0.01 | 39.5 ± 10.1 | 37.4 ± 10.1 | 0.002 |
| Myosteatosis | 590 (30.7) | 117 (21.3) | 115 (27.1) | 0.04 | 160 (33.5) | 198 (42.0) | 0.006 |
| Time between acquisition of CT images, mo | 15.0 ± 3.8 | 15.0 ± 3.8 | 15.0 ± 3.8 | 0.87 | 15.0 ± 3.8 | 15.1 ± 3.7 | 0.81 |
| Change in body weight between acquisition of CT images, % | −0.4 ± 8.7 | 0.3 ± 2.7 | 0.3 ± 12.0 | 0.97 | −0.1 ± 2.7 | −2.1 ± 12.5 | 0.001 |
1Values are mean ± SD or n (%) unless otherwise indicated. The χ2 test was used to compare distributions of categorical variables and a t test for distributions of continuous variables. All statistical tests were 2-sided. CT, computed tomography; HU, Hounsfield Unit.