FIGURE 2.

Chemokine and Cytokine influence activation, recruitment and migration of neutrophils in APAP‐induced ALI. Various chemokine and cytokine influence the activation and recruitment of neutrophils in APAP‐induced ALI. Mitochondria‐derived formyl peptides recruit neutrophils to sites of liver necrosis via FPR1. Similarly, IL‐33, IL‐17 and activated Cot/tpl2 induced neutrophils infiltration whereas IL‐13 significantly attenuates APAP‐induced liver injury via decreased neutrophils recruitment. SOCS2 and GRPR antagonist can also inhibited infiltration of neutrophils via downregulating CXCL‐1 and CXCL‐2/8, respectively