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. Author manuscript; available in PMC: 2022 Jul 10.
Published in final edited form as: Cancer Lett. 2021 Apr 22;510:67–78. doi: 10.1016/j.canlet.2021.04.011

Figure 1. The structure of TIM3.

Figure 1.

The extracellular region of T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) consists of an IgV domain, a mucin domain, and a stalk domain. The transmembrane region consists of a transmembrane domain and the intracellular region consists of a cytoplasmic tail with five tyrosine residues. The IgV domain contains binding sites for its ligands. Phosphatidylserine (Ptdser), carcinoembryonic antigen-related cell adhesion molecule (CEACAM1), and high mobility group box 1 (HMGB1) bind to the FG-CC’ loop, while Gal9 binds to the N-linked glycan.