Table 1.

Receptor and Ligands for TIM3 and Gal9

Receptor/Ligands		Biological function of Receptor-Ligand interaction	References
TIM3	Gal9	In T cells: Immunosuppression, T cell apoptosis	[43]
		In NK cells: Immunostimulatory effect	[39]
		DCs: Immunostimulatory effect	[44]
		Macrophages: Immunosuppression	[45]
	Ptdser	Apoptotic cells recognition, and clearance of apoptotic cells (in DCs)	[25]
	CEACAM1	Suppresses T cell immunity	[23, 29]
	HMGB1	Inhibits tumor derived nucleic acid migration in DCs	[46]
Gal9	TIM3	As mentioned above
	Dectin-1	Macrophage dependent T cell immunity suppression	[40]
	4–1BB	Enhances cytokine secretion, enhances immune response	[42]
	CD40	Immunosuppressive effect	[41]