Table 3.

Cox regression analyses for recurrence-free survival with clinicopathological factors.

Factors	Univariate Cox regression			Multivariate Cox regression
	HR	95% CI	P value	HR	95% CI	P value
Age (< 51/≥ 51), years old	0.707	0.387-1.291	0.259
Sex (male/female)	1.210	0.656-2.230	0.541
Tumor location (head/body or tail)	1.205	0.657-2.209	0.547
Nerve invasion (no/yes)	1.321	0.717-2.435	0.373
Vessel invasion (no/yes)	0.806	0.426-1.525	0.507
WHO grade (1/2)	4.721	2.203-10.116	<0.001	2.451	1.041-5.769	0.040
WHO grade (1/3)	15.749	5.951-41.678	<0.001	12.136	3.983-36.975	<0.001
TNM stage (I/II)	3.975	1.196-13.206	0.024	3.862	1.020-14.627	0.047
TNM stage (I/III)	8.349	2.430-28.687	0.001	6.660	1.564-28.356	0.010
Neutrophils (< 8/≥ 8), per HPF	5.739	2.658-12.391	<0.001	5.987	2.652-13.516	<0.001
Macrophages (< 17/≥ 17), per HPF	3.344	1.684-6.639	0.001	3.675	1.777-7.601	<0.001
Neutrophil extracellular traps (negative/positive)	2.118	1.163-3.857	0.014	2.035	1.043-3.970	0.037
Macrophage extracellular traps (negative/positive)	2.433	1.283-4.615	0.006	3.017	1.493-6.096	0.002

CI, Confidence interval; HR, Hazard ratio; All factors used were categorical variables. WHO grades 2 and 3 were compared with WHO grade 1. TNM stages Ⅱ and Ⅲ were compared with TNM stage Ⅰ.