Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 18;12:678201. doi: 10.3389/fimmu.2021.678201

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Ni, Tang, Lu, Xu, Shao, Saaoud, Saredy, Liu, Drummer, Sun, Hu, Lopez-Pastrana, Luo, Jiang, Choi, Wang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

(A) In normal tissue Treg groups, 4 pathways were shared by Treg canonical secretomes and exosome secretomes. The 5 pathways in Treg groups were shared by caspase-1-dependent, and Caspase-4 dependent gasdermine-D secretomes. Canonical secretome, Exosome secretomes, Caspase-1-dependent and Caspase-4 dependent gasdermine-D pathways in normal spleen Treg and tissue Treg were analyzed by Venn diagram. The Treg canonical secretomes and Treg exosomes had 4 overlapped pathways. The caspase-1 dependent-gasdermin D secretomes and Caspase-4 dependent gasdermine-D secretomes had 5 overlapped pathways. (B) In benign disease tissue Treg groups, 15 pathways were shared by Treg canonical secretomes and Treg Exosome secretomes. Only one pathway was shared by Treg caspase-1-gasdermin D secretomes and Treg caspase-4 dependent gasdermine-D secretomes. (C) In malignant disease tissue Treg groups, 5 pathways were shared by Treg canonical secretomes and Treg Exosome secretomes. The 6 pathway was shared by Treg caspase-1-gasdermin D secretomes and Treg caspase-4 dependent gasdermine-D secretomes.