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. 2021 May 18;12:678201. doi: 10.3389/fimmu.2021.678201

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Copyright © 2021 Ni, Tang, Lu, Xu, Shao, Saaoud, Saredy, Liu, Drummer, Sun, Hu, Lopez-Pastrana, Luo, Jiang, Choi, Wang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A, B) All the upregulated genes and downregulated genes in tissue Treg groups were compared to anti-cytotoxic T cell antigen-4 (CTLA-4) antibody-treated Treg (CTLA-4 signaling suppressed) versus CTLA-4 signaling non-suppressed CONTROL CD4+ T cell dataset (GSE14716) to determine how many Treg genes were dependent on CTLA-4 signaling. (C) Treg DEG collaboration with CTLA-4 induced genes and CTLA-4 suppressed genes in anti-CTLA-4 datasets. (D) Treg DEG non-collaboration with CTLA-4 induced genes and CTLA-4 suppressed genes in anti-CTLA-4 datasets. (E) pathways identified in Treg genes and not collaborated with CTLA-4 signalling.