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. 2021 May 18;12:678201. doi: 10.3389/fimmu.2021.678201

Table 3C.

Lymphoid tissue Treg enriched more exosome pathways than non-lymphoid tissue Treg. A. Exosome gene numbers in benign disease Treg groups.

Datasets Category Treg source Type TotalDEG Exo up /DEG% Exo down /DEG%
GSE116347 Lymphoid Tumor bearing mouse (B16) spleen RNA-seq 1218 328 26.93 113 9.28
GSE116347 Lymphoid Tumor bearing mouse (MC38) spleen RNA-seq 1298 331 25.50 147 11.33
GSE116347 Lymphoid Tumor bearing mouse (CT26) spleen RNA-seq 905 236 26.08 92 10.17
GSE120280 Lymphoid Tumor bearing mouse (TC-1) spleen RNA-seq 1776 475 26.75 158 8.90
GSE139372 Non-lymphoid Melanoma Skin RNA-seq 1571 121 7.70 287 18.27
GSE120280 Non-lymphoid Tumor bearing mouse (TC-1) tumor RNA-seq 1933 419 21.68 270 13.97
GSE89225 Non-lymphoid Breast Tumor RNA-seq 1493 204 13.66 250 16.74
GSE116347 Non-lymphoid Tumor bearing mouse (B16) tumor RNA-seq 2462 572 23.23 375 15.23
GSE116347 Non-lymphoid Tumor bearing mouse (MC38) tumor RNA-seq 1651 415 25.14 268 16.23
GSE116347 Non-lymphoid Tumor bearing mouse (CT26) tumor RNA-seq 1393 188 13.50 376 26.99

IPA analysis was performed to identify upregulated commonly shared exosome pathways in malignant disease tissue Treg (cut off: p < 0.05 and |Z-score| >= 2). A total of 69 exosome pathways enriched in malignant Treg groups, including 35 commonly shared pathways and 34 specific pathways. The 42 of 69 exosome pathways were identified in the lymphoid tissue Treg. Vitamin-C Transport and Endothelin-1 Signaling were the most common enriched pathways. Cell Cycle Control of Chromosomal Replication, Cell Cycle Control of Chromosomal Replication, BEX2 Signaling Pathway, Cholesterol Biosynthesis III (via Desmosterol), Superpathway of Cholesterol Biosynthesis, Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol), Cholesterol Biosynthesis I and Glycolysis I were only commonly shared in non-lymphoid tissue Treg.

Exo, exosome; DEG, differentially expressed gene; DEG%, percentage in total DEG numbers.