Table 3C.
Datasets | Category | Treg source | Type | TotalDEG | Exo up | /DEG% | Exo down | /DEG% |
---|---|---|---|---|---|---|---|---|
GSE116347 | Lymphoid | Tumor bearing mouse (B16) spleen | RNA-seq | 1218 | 328 | 26.93 | 113 | 9.28 |
GSE116347 | Lymphoid | Tumor bearing mouse (MC38) spleen | RNA-seq | 1298 | 331 | 25.50 | 147 | 11.33 |
GSE116347 | Lymphoid | Tumor bearing mouse (CT26) spleen | RNA-seq | 905 | 236 | 26.08 | 92 | 10.17 |
GSE120280 | Lymphoid | Tumor bearing mouse (TC-1) spleen | RNA-seq | 1776 | 475 | 26.75 | 158 | 8.90 |
GSE139372 | Non-lymphoid | Melanoma Skin | RNA-seq | 1571 | 121 | 7.70 | 287 | 18.27 |
GSE120280 | Non-lymphoid | Tumor bearing mouse (TC-1) tumor | RNA-seq | 1933 | 419 | 21.68 | 270 | 13.97 |
GSE89225 | Non-lymphoid | Breast Tumor | RNA-seq | 1493 | 204 | 13.66 | 250 | 16.74 |
GSE116347 | Non-lymphoid | Tumor bearing mouse (B16) tumor | RNA-seq | 2462 | 572 | 23.23 | 375 | 15.23 |
GSE116347 | Non-lymphoid | Tumor bearing mouse (MC38) tumor | RNA-seq | 1651 | 415 | 25.14 | 268 | 16.23 |
GSE116347 | Non-lymphoid | Tumor bearing mouse (CT26) tumor | RNA-seq | 1393 | 188 | 13.50 | 376 | 26.99 |
IPA analysis was performed to identify upregulated commonly shared exosome pathways in malignant disease tissue Treg (cut off: p < 0.05 and |Z-score| >= 2). A total of 69 exosome pathways enriched in malignant Treg groups, including 35 commonly shared pathways and 34 specific pathways. The 42 of 69 exosome pathways were identified in the lymphoid tissue Treg. Vitamin-C Transport and Endothelin-1 Signaling were the most common enriched pathways. Cell Cycle Control of Chromosomal Replication, Cell Cycle Control of Chromosomal Replication, BEX2 Signaling Pathway, Cholesterol Biosynthesis III (via Desmosterol), Superpathway of Cholesterol Biosynthesis, Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol), Cholesterol Biosynthesis I and Glycolysis I were only commonly shared in non-lymphoid tissue Treg.
Exo, exosome; DEG, differentially expressed gene; DEG%, percentage in total DEG numbers.