Table 3C.

B.

Exosome Pathway	Spleen		Spleen		Spleen		Melanoma	Mouse lung Tumor	Breast cancer	Mouse Melanoma Tumor	Mouse colon Tumor
	GSE116347 B16	GSE116347 MC38		GSE116347 CT26		GSE120280 TC-1	GSE139372	GSE120280 TC-1	GSE89255	GSE116347 B16	GSE116347 MC38	GSE116347 CT26	Total
Vitamin-C Transport	↑	↑		↑		↑				↑	↑		6
Role of NFAT in Regulation of the Immune Response	↑	↑		↑		↑							4
Endothelin-1 Signaling	↑	↑		↑		↑		↑			↑		6
Endocannabinoid Neuronal Synapse Pathway	↑	↑		↑		↑							4
Glioblastoma Multiforme Signaling	↑	↑		↑									3
TREM1 Signaling	↑	↑		↑									3
Thrombin Signaling	↑	↑		↑				↑			↑		5
Wnt/Ca+ pathway	↑	↑		↑									3
Dendritic Cell Maturation	↑	↑				↑							3
Glutathione-mediated Detoxification	↑	↑				↑							3
Signaling by Rho Family GTPases	↑			↑		↑							3
PI3K Signaling in B Lymphocytes	↑			↑		↑		↑			↑		5
Synaptic Long Term Depression	↑			↑									2
Estrogen Receptor Signaling	↑			↑									2
UVA-Induced MAPK Signaling	↑			↑				↑			↑		4
Chemokine Signaling	↑			↑									2
Phospholipases	↑			↑									2
Death Receptor Signaling	↑			↑									2
Cardiac Hypertrophy Signaling	↑					↑							2
Phospholipase C Signaling	↑					↑							2
IL-15 Production	↑					↑							2
Neuroinflammation Signaling Pathway		↑		↑									2
IL-8 Signaling				↑		↑		↑			↑		4
Rac Signaling				↑		↑		↑		↑			4
Cell Cycle Control of Chromosomal Replication								↑	↑	↑	↑		4
BEX2 Signaling Pathway									↑		↑		2
Cholesterol Biosynthesis III (via Desmosterol)										↑	↑		2
Superpathway of Cholesterol Biosynthesis										↑	↑		2
Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol)										↑	↑		2
Cholesterol Biosynthesis I										↑	↑		2
Glycolysis I										↑	↑		2
Shared (Total)	21 (29)	11 (14)		19 (25)		13 (14)	0	7 (21)	2 (3)	8 (13)	13 (25)	0
Specific = total - shared	8	3		6		1	0	14	1	5	12	0

All specific pathways will put in supplementary data ( Supplementary Table 6C ).