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. 2021 May 18;12:678201. doi: 10.3389/fimmu.2021.678201

Table 3D.

Gene numbers of caspase-4 dependent GSDMD secretomes were more than caspase-1 dependent GSDMD secretomes in various Treg groups.

Datasets Category Treg source Type Total DEG Casp-1up /DEG% Casp-1down /DEG% Casp-4 up /DEG% Casp-4 down /DEG%
GSE119169 Lymphoid Spleen Array 44 0 0.00 0 0.00 2 4.55 0 0.00
GSE37532 Lymphoid Lymph node Array 397 8 2.02 0 0.00 12 3.02 0 0.00
E-MTAB-7961 Lymphoid Spleen RNA-seq 1802 15 0.83 3 0.17 35 1.94 9 0.50
GSE20366 Non-lymphoid Small intestinal lamina propria Array 756 16 2.12 11 1.46 15 1.98 11 1.46
GSE64909 Non-lymphoid Brown adipose tissue Array 113 8 7.08 0 0.00 8 7.08 0 0.00
GSE37532 Non-lymphoid Visceral adipose tissue(VAT) Array 924 18 1.95 2 0.22 22 2.38 5 0.54
E-MTAB-7961 Non-lymphoid Kidney RNA-seq 1584 20 1.26 4 0.25 42 2.65 5 0.32
GSE50096 Lymphoid Skeletal muscle injured 2w spleen Array 308 6 1.95 0 0.00 10 3.25 1 0.32
GSE50096 Lymphoid Skeletal muscle injured 4d spleen Array 313 7 2.24 0 0.00 13 4.15 1 0.32
E-MTAB-7961 Non-lymphoid Fibrosis kidney RNA-seq 2440 13 0.83 4 0.25 37 2.36 8 0.51
E-MTAB-7961 Non-lymphoid Regeneration kidney RNA-seq 2365 25 1.06 6 0.25 56 2.37 7 0.30
GSE50096 Non-lymphoid Skeletal muscle injured 2w muscle Array 539 10 1.86 0 0.00 11 2.04 5 0.93
GSE50096 Non-lymphoid Skeletal muscle injured 4d muscle Array 465 10 2.15 2 0.43 10 2.15 8 1.72
GSE116347 Lymphoid Tumor bearing mouse (B16) spleen RNA-seq 1218 20 1.64 3 0.25 35 2.87 3 0.25
GSE116347 Lymphoid Tumor bearing mouse (MC38) spleen RNA-seq 1298 18 1.39 2 0.15 42 3.24 4 0.31
GSE116347 Lymphoid Tumor bearing mouse (CT26) spleen RNA-seq 905 14 1.55 1 0.11 28 3.09 2 0.22
GSE120280 Lymphoid Tumor bearing mouse (TC-1) spleen RNA-seq 1776 21 1.18 9 0.51 38 2.14 11 0.62
GSE139372 Non-lymphoid Melanoma Skin RNA-seq 1571 2 0.13 8 0.51 8 0.51 19 1.21
GSE120280 Non-lymphoid Tumor bearing mouse (TC-1) tumor RNA-seq 1933 18 0.93 6 0.31 33 1.71 13 0.67
GSE89225 Non-lymphoid Breast Tumor RNA-seq 1493 9 0.60 6 0.40 16 1.07 18 1.21
GSE116347 Non-lymphoid Tumor bearing mouse (B16) tumor RNA-seq 2462 42 1.71 9 0.37 72 2.92 23 0.93
GSE116347 Non-lymphoid Tumor bearing mouse (MC38) tumor RNA-seq 1651 27 1.64 11 0.67 39 2.36 21 1.27
GSE116347 Non-lymphoid Tumor bearing mouse (CT26) tumor RNA-seq 1393 9 0.65 16 1.15 11 0.79 52 3.73

GSDMD, Gasdermin-D; Casp-1, caspase-1; Casp-4, caspase-4; DEG, differentially expressed gene.

However, the total numbers in each Treg datasets was too low to perform IPA analysis. The detailed lists were shown in Supplementary Table 7 .