Datasets	Category	Treg source	Type	TotalDEG	Exo up	/DEG%	Exo down	/DEG%
GSE50096	Lymphoid	Skeletal muscle injured 2w spleen	Array	308	96	31.17	28	9.09
GSE50096	Lymphoid	Skeletal muscle injured 4d spleen	Array	313	115	36.74	22	7.03
E-MTAB-7961	Non-lymphoid	Fibrosis kidney	RNA-seq	2440	379	15.53	109	4.47
E-MTAB-7961	Non-lymphoid	Regeneration kidney	RNA-seq	2365	541	22.88	131	5.54
GSE50096	Non-lymphoid	Skeletal muscle injured 2w muscle	Array	539	147	27.27	75	13.91
GSE50096	Non-lymphoid	Skeletal muscle injured 4d muscle	Array	465	94	20.22	101	21.72

IPA analysis was performed to identify upregulated commonly shared exosome pathways in benign disease tissue Treg. A total of 111 exosome pathways were enriched in benign disease Treg groups including 32 commonly shared and 79 specific pathways. The 71 of 79 specifically enriched pathways were in E-MTAN-7961 Treg. Vitamin-C Transport and Th2 Pathways were enriched in GSE50096 2W spleen Treg. TREM1 Signaling was enriched in GSE50096 4D spleen Treg. PTEN Signaling was enriched in GSE50096 4D muscle Treg. Dendritic Cell Maturation, Apelin Endothelial Signaling Pathway, and Bladder Cancer Signaling were enriched in E-MTAB-7961 fibrosis Treg. The 71 specifically enriched pathways in E-MTAB-7961 regeneration Treg were shown in Supplementary Table 6B . (cut off: p < 0.05 and |Z-score| >= 2).