Table 3b.

B.

Exosome Pathway	Spleen	Spleen	Kidney		Muscle
	GSE50096 2W	GSE50096 4D	E-MTAB-7961 F	E-MTAB-7961 R	GSE50096 2W	GSE50096 4D	Total
Cardiac Hypertrophy Signaling	↑	↑	↑	↑			4
Role of NFAT in Regulation of the Immune Response	↑	↑	↑				3
Synaptic Long Term Depression		↑	↑	↑			3
PI3K Signaling in B Lymphocytes		↑	↑	↑			3
Adrenomedullin signaling pathway		↑	↑	↑			3
Chemokine Signaling		↑	↑	↑			3
Xenobiotic Metabolism CAR Signaling Pathway	↑					↑	2
Endocannabinoid Neuronal Synapse Pathway		↑	↑				2
Necroptosis Signaling Pathway		↑		↑			2
Neuroinflammation Signaling Pathway		↑		↑			2
Reelin Signaling in Neurons			↑	↑			2
White Adipose Tissue Browning Pathway			↑	↑			2
Hepatic Fibrosis Signaling Pathway			↑	↑			2
GDNF Family Ligand-Receptor Interactions			↑	↑			2
UVA-Induced MAPK Signaling			↑	↑			2
Glioblastoma Multiforme Signaling			↑	↑			2
STAT3 Pathway			↑	↑			2
IL-8 Signaling			↑	↑			2
Phospholipases			↑	↑			2
Sphingosine-1-phosphate Signaling			↑	↑			2
Wnt/Ca+ pathway			↑	↑			2
Cholecystokinin/Gastrin-mediated Signaling			↑	↑			2
PDGF Signaling			↑	↑			2
p70S6K Signaling			↑	↑			2
IL-15 Production			↑	↑			2
Estrogen-Dependent Breast Cancer Signaling			↑	↑			2
Estrogen Receptor Signaling			↑	↑			2
Factors Promoting Cardiogenesis in Vertebrates			↑	↑			2
Thrombin Signaling			↑	↑			2
FcγRIIB Signaling in B Lymphocytes			↑	↑			2
Endothelin-1 Signaling			↑	↑			2
Glutathione-mediated Detoxification			↑	↑			2
T Cell Exhaustion Signaling Pathway				↑	↑		2
Shared (Total)	3(5)	9(10)	29(32)	30(101)	1(1)	1(2)
Specific = total – shared	2	1	3	71	0	1