Figure 3.

The atlas of polygenic risk score (PRS) associations at mrcieu.mrsoftware.org/PRS_atlas can be helpful in terms of generating hypotheses for future analyses in causal inference. For example, the plot displayed here represents the association between the ischemic stroke PRS and 551 outcomes. The only points that survive multiple testing here (indicated by the dashed red line) represent outcomes related to blood pressure and the ICD-10 for ischemic heart disease. This is likely due to blood pressure being an established risk factor for heart disease, as well as stroke and heart disease having a shared etiology. Similar lookups can be performed for all 162 PRSs in this atlas.