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Whole genome CRISPR/Cas9 screen identifies potential therapeutic targets and pathways in SCLC (A) Schematic of the CRISPR/Cas9 dropout screen conducted using the GeCKO v2 lentiviral mouse library. (B,C) Volcano plots of MAGeCK analysis results from five screened mSCLC cell lines (B) and three screened Trp53-null MEF isolates (C). (D) CRISPR score heat map of the top depleted and enriched genes for each of the five mSCLC cell lines and three Trp53-null MEF isolates screened.
