Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun;31(6):968–980. doi: 10.1101/gr.269951.120

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Nakamura et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see https://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Figure 4. — CTCF-mediated loops are associated with late-activating genes. (A) Classification of zygotically expressed genes into seven (A to G) groups by expression dynamics. (B) Fraction of genes for each class is shown for loop genes and nonloop genes. Loop genes are enriched with genes activated from mid-gastrula (17 hpf) or later (gene class E, F, and G). (C) Examples of loop-associating late-activating genes. Normalized observed Hi-C contacts as a heat map at 10-kb resolution and RNA-seq tracks are shown. Loops emerge from 17 hpf (mid-gastrula) between irx genes, and transcription is activated at this stage.