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. 2021 Jun;31(6):1047–1059. doi: 10.1101/gr.274373.120

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© 2021 Bohm et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see https://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 7. — Working model of role of RSC in NER. Our data suggest RSC plays a role in both subpathways of NER. (A) In GG-NER, we propose RSC is recruited to UV damage through Rad4 and is subsequently tasked with remodeling nucleosomes in order to increase accessibility to TFIIH and/or other downstream NER proteins. (B) In TC-NER, RSC may be recruited to remodel nucleosomes to induce RNA Pol II backtracking, or may directly act on RNA Pol II and aid in its eviction from the CPD lesion to promote subsequent repair.