Table 1.

LMP1 interacting proteins^*

No.	Protein	Method	LMP1 domain	Pathway	Reference
1	TRAF1	IP	CTAR1	NF-KB activation	[67]
2	TRAF2	IP	CTAR1	NF-KB activation	[67]
3	TRAF3	IP	CTAR1	Inhibition/activation of NF-KB	[55]
4	TRAF5	IP	CTAR1	LMP1-mediated c-Jun kinase signaling	[197],[198]
5	TRAF6	IP	CTAR2	NF-KB activation, JNK activation	[98],[199]
6	CD63	IP, Microscopy	LMP1	LMP1 exosomal targeting, downregulation of NF-KB	[83]
7	A20	IP	CTAR1/CTAR2	NF-KB &JNK inhibition	[138]
9	Bram1	IP, GST-PD	CTAR2	NF-KB inhibition, not JNK	[139]
10	SCFHOS/bTrcP	IP, In-vitro assay	C-terminal	NF-KB inhibition	[141]
11	PRA1	Y2H, FRET, BRET	TM	NF-KB activation	[79]
12	Galectin	IP, Proteomics	LMP1	Immune response	[88]
13	BS69	Y2H	C-terminal	JNK activation	[98]
14	TNIK	IP, Proteomics	CTAR2	Canonical NF-KB & JNK	[99]
15	RIPK1/3	IP, PLA assay	CTAR2	Suppress necroptosis	[96]
16	TRADD	IP,Y2H	CTAR2	Activate NF-KB, not JNK	[57]
17	RIP	Y2H	CTAR2	Activate NF-KB	[93]
18	IRF7	IP, microscopy		Activates IRF7	[103]
19	Ubc9	IP	CTAR3	Increased sumoylation of proteins	[60]
20	RNF31	IP	CTAR2	Activate NF-KB	[105]
21	Actinin-1	BIFC	CTAR1	Downregulate NF-KB	[123]
22	Actinin-4	BIFC	CTAR1	Downregulate NF-KB	[123]
23	Gelsolin	BIFC, IP	CTAR1	Downregulate NF-KB	[123],[127]
24	Tropomyosin	BIFC	LMP1	May be lipid raft targeting or regulate motility and invasion	[123]
25	Tmem134	BIFC, IP	CTAR1/CTAR2	Activate NF-KB	[125]
26	FGD4	IP	TM	Cdc42 activation, migration	[128]
27	RPS27a	IP, GST-PD	LMP1	Suppress LMP1 degradation	[106]
28	Id1	IP	CTAR1	Suppress LMP1 degradation	[107]
29	GLUT1	IP, IF	CTAR3	MDSC expansion, resistance to host defense	[91]
30	Src	IP	CTAR1	IRF4 activation	[110]
31	PDK1	IP, Microscopy	LMP1	Increased cell survival	[110]
32	PI3K (p85 subunit)	IP	CTAR1	Transformation and survival	[111]
33	vimentin	IP, proteomics	CTAR1	Transformation of fibroblast	[133].

^*Proteins identified in high through-put studies are not included