Table 1. Histopathological features of three bone epithelioid hemangioma cases.

OPD: outpatient department

Case

Age

Sex

Location

Clinical Setting

Radiology

Clinical Impression

Treatment and Follow-Up

Overall Architecture

Pattern of Vascular Proliferation

Presence of Epithelioid Endothelial Cells

Predominant inflammatory Cell Component and Distribution

Distribution and Depth of Inflammation

Molecular Study

1

15

M

Second metatarsal

Casualty patient with slowly growing swelling in the forefoot for 2 years.

Ill-defined osteolytic lesion with expansile margins.

Enchondroma

Patient treated with bone curettage and there was no recurrence on follow-up. Patient was declared cured and no subsequent treatment was given on follow-up.

Nodular lobular pattern without demonstrable vessel origin.

Central diffuse growth in sheets. Peripheral well-formed blood vessels. Focal spindling of cells arranged in fascicles with slit-like vasculature.

Well-formed vessels toward the periphery showing epithelioid endothelial cells with prominent hobnailing.

Eosinophils along with lymphocytes and plasma cells.

Diffuse and extending into the deep dermis of the overlying skin.

Not done due to patient’s disinterest.

2

25

F

Carpal bone

OPD patient with insidious onset and progressive swelling in the wrist.

Ill-defined osteolytic lesion with cortical erosion and periosteal reactive bone formation.

Aneurysmal bone cyst

Patient treated with bone curettage and there was no recurrence on follow-up. Patient was declared cured and no subsequent treatment was given on follow-up.

Nodular lobular pattern without demonstrable vessel origin.

Central diffuse growth in sheets. Peripheral well-formed blood vessels. Focal spindling of cells arranged in fascicles with slit-like vasculature.

Well-formed vessels toward the periphery showing epithelioid endothelial cells.

Eosinophils along with lymphocytes and plasma cells.

Diffuse.

Not done due to patient’s disinterest.

3

20

M

First metatarsal

Casualty patient with progressive insidious onset and slowly growing swelling in the forefoot for 1 year.

Ill-defined expansile sclerotic lesion with reactive bone formation and periosteal reaction.

Enchondroma

Patient treated with bone curettage and there was no recurrence on follow-up. Patient was declared cured and no subsequent treatment was given on follow-up.

Nodular lobular pattern without demonstrable vessel origin.

Central diffuse growth in sheets. Peripheral well-formed blood vessels.

Well-formed vessels toward the periphery showing epithelioid endothelial cells with prominent hobnailing.

Eosinophils along with lymphocytes and plasma cells.

Diffuse and extending into the deep dermis of the overlying skin.

Not done due to patient’s disinterest.