Table 4. Distinguishing EH from Kimura’s disease.
EH: epithelioid hemangioma
Epithelioid haemangioma | Kimura’s disease | |
Ethnicity | Occurs in all ethnicities [57]. | Predominantly affects Asian males [57]. |
Location | Superficial and smaller lesions [57]. | Subcutaneous involvement with extension to lymph nodes, underlying soft tissue, and salivary glands [57]. |
Complete blood counts and serology | Lacks high IgE and eosinophils in peripheral blood [57]. | High IgE, eosinophils in peripheral blood, and eosinophilia. Could be misdiagnosed as nephrotic syndrome, asthma, tuberculosis, or Loeffler syndrome [57]. |
Epithelioid morphology | Epithelioid endothelial cells line all blood vessels [57]. | Proliferation of post-capillary venules lined by plump endothelial cells [57]. |
Overlapping morphologic features | Lymph follicles with germinal center formation and abundant eosinophils (less intense than in Kimura’s disease) [57]. | Lymph follicles with germinal center formation and abundant eosinophils (more intense than in EH) [57]. |
Eosinophilic microabscesses and Charcot–Leyden crystals | Negative [57]. | Present [57]. |