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. 2021 Jun 1;13(6):e15371. doi: 10.7759/cureus.15371

Table 4. Distinguishing EH from Kimura’s disease.

EH: epithelioid hemangioma

  Epithelioid haemangioma Kimura’s disease
Ethnicity Occurs in all ethnicities [57]. Predominantly affects Asian males [57].
Location Superficial and smaller lesions [57]. Subcutaneous involvement with extension to lymph nodes, underlying soft tissue, and salivary glands [57].
Complete blood counts and serology Lacks high IgE and eosinophils in peripheral blood [57]. High IgE, eosinophils in peripheral blood, and eosinophilia. Could be misdiagnosed as nephrotic syndrome, asthma, tuberculosis, or Loeffler syndrome [57].
Epithelioid morphology Epithelioid endothelial cells line all blood vessels [57]. Proliferation of post-capillary venules lined by plump endothelial cells [57].
Overlapping morphologic features Lymph follicles with germinal center formation and abundant eosinophils (less intense than in Kimura’s disease) [57]. Lymph follicles with germinal center formation and abundant eosinophils (more intense than in EH) [57].
Eosinophilic microabscesses and Charcot–Leyden crystals Negative [57]. Present [57].