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. 2021 May 27;28(1):995–1006. doi: 10.1080/10717544.2021.1928794

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — The internalization of cRGD-PSH-NP/S under high magnification (63×) and the down regulation of survivin protein expression in HepG2 cells. (A) Intracellular localization of 5′-Cy3-labled siRNA delivered by cRGD-PSH-NP/S under high magnification (63×) with FBS. (B) The down regulation of survivin protein expression in HepG2 cells treated with PEI-NP/S, PSH-NP/S, cRGD-NP/S and cRGD-PSH-NP/S (*p < .05 vs control; **p < .01 vs control; ^#p < .05 vs PEI-NP/S; ^##p < .01 vs PEI-NP/S).