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A) Forest plot of pooled incidence rate (patient-years) for HER2+ MBC. Random effects model presented. Incidence per year of follow-up ranged from 0.04 to 0.27. Median follow-up times ranged from 5.8 to 53.6 months. B) Funnel Plot for publication bias according to studies reporting brain metastasis in HER2+ MBC. Egger’s test; P = 0.30. HER2+, human epidermal growth factor receptor-2 positive; MBC, metastatic breast cancer.
