Fig. 6.

Systemic administration of mB7-H3-CAR T cells is safe. High dose (1 × 10⁷) of NT and mB7-H3-CAR T cells expressing GFP.ffluc were injected i.v. into tumor-free albino C57BL/6 mice. A. Representative dorsal bioluminescence images. B. Radiance signal (total flux) over time (n = 5, 2-way ANOVA with Sidak’s test for multiple comparisons; **P < .01; ns, nonsignificant). C. Change in murine body weight after T-cell injection. D. Representative images of H&E-stained sections for each treatment group are shown at 40× magnification, scale bar: 100 µm.