Table 2.
Multivariate analysis of impact of renal dysfunction measured by eGFR on overall survival in discovery cohort.
| Factor | Count | Event | HR | 95% CI | P-value |
|---|---|---|---|---|---|
| Renal function groups | <.0001 | ||||
| GFR ≥90 | 4234 | 2390 | 1 | ||
| GFR 60-89 | 3157 | 1858 | 1 | (0.95, 1.06) | 0.98 |
| GFR 45-59 | 537 | 336 | 1.17 | (1.02, 1.34) | 0.03 |
| GFR <45 | 169 | 124 | 1.63 | (1.33, 2.01) | <.0001 |
| HCT-CI (excluding renal function) | <.0001 | ||||
| 0 | 1995 | 1061 | 1 | ||
| 1 | 1086 | 594 | 1.08 | (0.97, 1.21) | 0.16 |
| 2 | 1118 | 601 | 1.11 | (0.97, 1.28) | 0.13 |
| 3 | 1445 | 842 | 1.18 | (1.07, 1.29) | 0.0006 |
| 4 | 908 | 564 | 1.26 | (1.12, 1.42) | 0.0001 |
| 5 | 557 | 358 | 1.5 | (1.33, 1.7) | <.0001 |
| 6 | 371 | 247 | 1.5 | (1.24, 1.82) | <.0001 |
| 7 | 200 | 148 | 1.81 | (1.46, 2.24) | <.0001 |
| 8 | 98 | 85 | 3 | (2.32, 3.88) | <.0001 |
| 9+ | 77 | 57 | 1.8 | (1.31, 2.49) | 0.0003 |
| Patient age | <.0001 | ||||
| 40-49 | 1637 | 871 | 1 | ||
| 50-59 | 2782 | 1589 | 1.18 | (1.07, 1.31) | 0.001 |
| 60-69 | 3084 | 1876 | 1.33 | (1.18, 1.49) | <.0001 |
| ≥70 | 594 | 372 | 1.48 | (1.27, 1.73) | <.0001 |
| Donor age (HLA-identical sibling or other relative; years) | 0.0083 | ||||
| <18 | 18 | 6 | 1 | ||
| 18-29 | 2294 | 1242 | 1.86 | (0.83, 4.17) | 0.13 |
| 30-39 | 1265 | 731 | 2.05 | (0.91, 4.6) | 0.08 |
| 40-49 | 1221 | 708 | 2.16 | (0.96, 4.87) | 0.06 |
| ≥50 | 2090 | 1215 | 2.29 | (0.99, 5.27) | 0.05 |
| Donor type | <.0001 | ||||
| HLA-identical sibling | 2176 | 1206 | 1 | ||
| Haploidentical | 638 | 343 | 1.2 | (1.01, 1.44) | 0.04 |
| Other related | 147 | 94 | 1.33 | (1, 1.78) | 0.05 |
| Well-matched unrelated | 3355 | 1884 | 1.19 | (1.05, 1.34) | 0.007 |
| Partially-matched unrelated | 671 | 441 | 1.44 | (1.24, 1.69) | <.0001 |
| Mis-matched unrelated | 33 | 26 | 1.85 | (1.28, 2.67) | 0.001 |
| Unrelated (matching unknown) | 95 | 48 | 1.48 | (1.06, 2.06) | 0.02 |
| Cord blood | 919 | 625 | NA | ||
| DRI-R groupings | <.0001 | ||||
| Low | 763 | 363 | 1 | ||
| Intermediate | 4350 | 2300 | 1.19 | (1.04, 1.38) | 0.01 |
| High | 2560 | 1744 | 1.9 | (1.62, 2.23) | <.0001 |
| Very high | 252 | 186 | 2.69 | (2.08, 3.47) | <.0001 |
| Karnofsky performance score | <.0001 | ||||
| 90-100 | 4671 | 2552 | 1 | ||
| < 90 | 3254 | 2053 | 1.26 | (1.16, 1.37) | <.0001 |
| Missing | 172 | 103 | 1.12 | (0.87, 1.44) | 0.37 |
| Previous autologous transplant | 0.06 | ||||
| No | 7567 | 4364 | 1 | ||
| Yes | 465 | 295 | 1.14 | (0.98, 1.32) | 0.09 |
| Missing | 65 | 49 | 1.45 | (0.98, 2.14) | 0.06 |
| Year of transplant | <.0001 | ||||
| 2008-2011 | 3141 | 2111 | 1 | ||
| 2012-2016 | 4956 | 2597 | 0.81 | (0.75, 0.87) | <.0001 |
*
Note: stratified variables: graft type, conditioning regimen, conditioning regimen intensity, disease group, ATG/Campath, GVHD prophylaxis. NA, not applicable.