Table 3.
Multivariate analysis of impact of renal dysfunction measured by eGFR on non-relapse mortality in discovery cohort.
| Factor | Count | Event | HR | 95% CI | P-value |
|---|---|---|---|---|---|
| Renal function groups | <.0001 | ||||
| GFR ≥90 | 3188 | 693 | 1 | ||
| GFR 60-89 | 2532 | 617 | 1.12 | (0.99, 1.26) | 0.07 |
| GFR 45-59 | 436 | 126 | 1.46 | (1.21, 1.76) | 0.0001 |
| GFR < 45 | 138 | 49 | 1.74 | (1.19, 2.54) | 0.004 |
| HCT-CI (excluding renal function) | <.0001 | ||||
| 0 | 1560 | 330 | 1 | ||
| 1 | 825 | 179 | 1.21 | (1.01, 1.45) | 0.04 |
| 2 | 848 | 185 | 1.13 | (0.89, 1.45) | 0.31 |
| 3 | 1126 | 258 | 1.18 | (0.96, 1.45) | 0.12 |
| 4 | 686 | 176 | 1.41 | (1.1, 1.82) | 0.008 |
| 5 | 426 | 98 | 1.38 | (1.07, 1.79) | 0.01 |
| 6 | 305 | 88 | 1.87 | (1.36, 2.56) | 0.0001 |
| 7 | 164 | 53 | 2.02 | (1.4, 2.92) | 0.0002 |
| 8 | 86 | 38 | 4.66 | (3.22, 6.76) | <.0001 |
| 9+ | 59 | 18 | 2.32 | (1.39, 3.88) | 0.001 |
| Patient age | 0.01 | ||||
| 40-49 | 1204 | 255 | 1 | ||
| 50-59 | 2137 | 525 | 1.27 | (1.06, 1.52) | 0.008 |
| 60-69 | 2475 | 581 | 1.43 | (1.15, 1.77) | 0.001 |
| ≥70 | 478 | 124 | 1.67 | (1.2, 2.32) | 0.002 |
| Conditioning intensity | <.0001 | ||||
| Myeloablative | 2683 | 714 | 1 | ||
| RIC | 2427 | 538 | 0.64 | (0.51, 0.8) | 0.0001 |
| NMA | 1167 | 230 | 0.51 | (0.38, 0.69) | <.0001 |
| Donor age (HLA-identical sibling or other relative; years) | 0.003 | ||||
| <18 | 14 | 2 | 1 | ||
| 18-29 | 1833 | 422 | 1.07 | (0.15, 7.83) | 0.95 |
| 30-39 | 983 | 239 | 1.11 | (0.15, 8.2) | 0.92 |
| 40-49 | 928 | 208 | 1.3 | (0.18, 9.55) | 0.80 |
| ≥50 | 1665 | 339 | 1.57 | (0.21, 11.88) | 0.66 |
| Donor type | <.0001 | ||||
| HLA-identical sibling | 1718 | 301 | 1 | ||
| Haploidentical | 473 | 99 | 1.8 | (1.37, 2.38) | <.0001 |
| Other related | 126 | 26 | 2.11 | (1.25, 3.54) | 0.005 |
| Well-matched unrelated | 2648 | 651 | 2.01 | (1.66, 2.43) | <.0001 |
| Partially-matched unrelated | 502 | 152 | 2.56 | (2.02, 3.25) | <.0001 |
| Mis-matched unrelated | 29 | 10 | 2.14 | (1.17, 3.92) | 0.01 |
| Unrelated (matching unknown) | 71 | 14 | 2.25 | (1.15, 4.4) | 0.02 |
| Cord blood | 664 | 214 | 3.3 | (0.44, 24.92) | 0.25 |
| Patient ethnicity | 0.003 | ||||
| Hispanic or Latino | 364 | 86 | 1 | ||
| Not Hispanic or Latino | 5651 | 1330 | 0.94 | (0.71, 1.23) | 0.64 |
| Non-resident of the U.S. | 216 | 57 | 1.96 | (1.19, 3.24) | 0.009 |
| Karnofsky performance score | 0.0001 | ||||
| 90-100 | 3586 | 791 | 1 | ||
| < 90 | 2570 | 653 | 1.36 | (1.19, 1.55) | <.0001 |
| Year of transplant | <.0001 | ||||
| 2008-2011 | 2429 | 687 | 1 | ||
| 2012-2016 | 3865 | 798 | 0.7 | (0.6, 0.81) | <.0001 |
*
Note: stratified variables: DRI-R groupings, disease group, conditioning regimen, GVHD prophylaxis.