Table 1. Participant characteristics of those screened for the ADEPTT Study, with transminase results at screening (n = 1301).
| Characteristic | N (%) or median (IQR) |
|---|---|
| Self-reported current alcohol use | |
| No, abstained for ≥1 year | 424 (32.6%) |
| Yes, prior 3 months | 877 (67.4%) |
| Sex | |
| Male | 612 (47.0%) |
| Female | 689 (53.0%) |
| BMI (n = 1215) | 23.4 (21.0–27.0) |
| < 18.5 | 72 (5.9%) |
| 18.5 - < 25 | 690 (56.8%) |
| 25 - < 30 | 279 (23.0%) |
| > = 30 | 174 (14.3%) |
| Age | 39 (32–46) |
| 18–35 | 465 (35.7%) |
| 36–43 | 407 (31.3%) |
| 44+ | 429 (33.0%) |
| ART regimen | |
| Dolutegravir-based | 233 (17.9%) |
| NNRTI-based | 960 (73.8%) |
| PI-based | 108 (8.3%) |
| Prior unhealthy alcohol use? (AUDIT-C hazardous and/or PEth > = 50) (n = 330) | |
| No | 155 (47.0%) |
| Yes | 175 (53.0%) |
| ALT | |
| < 1.25x ULN | 1132 (87.0%) |
| > = 1.25 - <5x ULN | 164 (12.6%) |
| > = 5 - <10x ULN | 3 (0.2%) |
| > = 10x ULN | 2 (0.2%) |
| AST | |
| < 1.25x ULN | 1103 (84.8%) |
| > = 1.25 - <5x ULN | 186 (14.3%) |
| > = 5 - <10x ULN | 11 (0.9%) |
| > = 10x ULN | 1 (0.1%) |
| ALT/AST grade (highest grade of the 2) | |
| Grade 0 (<1.25x ULN) | 1056 (81.2%) |
| Grade 1 (1.25 - <2.5x ULN) | 192 (14.8%) |
| Grade 2 (2.5 - <5x ULN) | 39 (3.0%) |
| Grade 3 (5- <10x ULN) | 12 (0.9%) |
| Grade 4 (> = 10x ULN) | 2 (0.2%) |