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. 2021 May 13;32(4):508–517. doi: 10.1097/EDE.0000000000001366

TABLE 2.

Two-by-two Tables for Traditional Case-control and Test-negative Design Studies

Design Exposure Outcome
Traditional case-control Case Control
Vaccinated graphic file with name ede-32-508-i041.jpg graphic file with name ede-32-508-i042.jpg
Unvaccinated graphic file with name ede-32-508-i043.jpg graphic file with name ede-32-508-i044.jpg
Test-negative design
Test positive Test negative
Vaccinated graphic file with name ede-32-508-i045.jpg graphic file with name ede-32-508-i046.jpg
Unvaccinated graphic file with name ede-32-508-i047.jpg graphic file with name ede-32-508-i048.jpg

Contents of the table are probabilities of the various listed outcomes, accounting for vaccinated or unvaccinated status. Parameters: Inline graphic, proportion of the population vaccinated; Inline graphic, risk of the outcome of interest; Inline graphic, risk of the negative-control outcome; Inline graphic, relative risk of the outcome of interest, given vaccination (see Table 1).