Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
PTCH-SMO activation. PTCH1 prevents access of sterols to SMO or pumps sterols away from SMO, thereby inhibiting SMO activation. HH binding to PTCH1 prevents this inhibition, thus allowing sterols to activate SMO. (Reproduced from Curr Opin Struct Biol. 2019; 57:204–214. Kowatsch et al., Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signaling (43)). Abbreviations: HH, hedgehog; PTCH, Patched; SMO, Smoothened.
