Table II.
Proportions of participants with a change (or no change) in threshold, (overall and cohorted into those with lower reaction thresholds to peanut), by IPD meta-analysis results
| Cumulative reaction threshold at initial challenge (mg of peanut protein) | At IPD meta-analysis, the proportion of participants (and 95% CI) with |
||||||
|---|---|---|---|---|---|---|---|
| Increase in threshold |
No change in threshold | Decrease in threshold |
±Max half-log change | ± Max 1-log change | |||
| > Half-log | Any | Any | > Half-log | ||||
| Any (n = 534) | 18.3% (11.0-28.9) | 35.5% (26.1-46.3) | 32.2% (25.3-40.0) | 30.3% (24.5-36.9) | 8.2% (4.5-14.5) | 71.2% (56.2-82.6) | 91.2% (84.1-95.3) |
| >150 mg (ie, no objective symptoms in response to ½ peanut) (n = 113) | 3.2% (0.5-16.5) | 15.6% (10.3-23.9) | 28.3% (20.8-37.3) | 59.6% (42.1-75.0) | 11.9% (6.2-21.6) | 85.0% (77.1-90.4) | 96.5% (90.4-98.8) |
| <150 mg (n = 423) | 22.5% (14.5-33.2) | 40.1% (30.7-50.2) | 34.5% (25.6-44.7) | 23.0% (19.3-27.3) | 7.0% (3.5-13.6) | 68.1% (53.9-79.7) | 89.9% (82.9-94.2) |
| <50 mg (n = 213) | 35.7% (28.1-44.1) | 56.6% (47.0-65.8) | 28.7% (21.8-36.7) | 15.0% (10.8-20.5) | 6.6% (3.9-10.9) | 56.9% (47.7-65.6) | 81.7% (75.9-86.3) |
| ≤15 mg (n = 101) | 50% (38-62) | 72% (63-80) | 21% (12-35) | 5.0% (2.1-11) | 2.8% (0.7-11) | 44% (30-59) | 68% (59-77) |
| ≤5 mg (n = 56) | 63% (47-77) | 82% (70-90) | 10% (2.6-31) | 5.4% (1.7-15) | 5.4% (1.7-15) | 24% (8-53) | 61% (47-73) |
max, Maximum.
A half-log or 1-log change in threshold is equivalent to a shift in reaction threshold by 1 or 2 dosing increments when a challenge protocol based on PRACTALL is used. Boldface highlights "no change in threshold" and "+/- max 1/2-log change" which are arguably the most important outcome measures.