Table III.

Probability of the occurrence of anaphylaxis at a subsequent FC event

Symptoms at subsequent FC	Anaphylaxis			Non-anaphylaxis in response to the same or a higher dose
Symptoms at at index FC	In response to a lower dose (compared with the response to the index reaction)	In response to a lower or same level of exposure	In response to a higher dose∗
Anaphylaxis
In response to any dose (n = 100)	12% (6-20)	25% (17-35)	8% (4-15)	35% (26-45)
In response to <50 mg (n = 23)	4.4% (0.1-22)	22% (7-44)	9% (1-28)	43% (23-66)
Nonanaphylaxis
In response to any dose (n = 52)	19% (6-20)	50% (36-64)
In response to <50 mg (n = 23)	4.4% (0.1-22)	30% (13-53)

In all data cells, the intervals in parentheses are 95% CIs.

^∗These data must be interpreted with caution, as the risk of anaphylaxis in response to higher doses would have reduced by the challenge being terminated in many individuals at the onset of objective symptoms (before the onset of anaphylaxis), thus potentially limiting reaction severity.