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. 2021 May 28;13:4271–4281. doi: 10.2147/CMAR.S297316

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© 2021 Lin et al.

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Real-time qRT–PCR comparison of the relative expression (normalized to GAPDH) of 22 selected circRNAs in 20 paired neuroblastoma specimens and adjacent normal fetal adrenal medulla. Student t-test P values are shown in the figure. (A) Among ten selected highly up-regulated circRNAs from circRNA-seq, eight were confirmed to be significantly up-regulated in neuroblastoma, with P < 0.05. (B) Among five selected highly down-regulated circRNAs from circRNA-seq, two were confirmed to be significantly down-regulated in neuroblastoma, with P < 0.05. (C) Among seven selected miR-21 related circRNAs from circRNA-seq, three were confirmed to be significantly down-regulated in neuroblastoma, with P < 0.05.