Table 3.
Association Analysis Result Between IL1R2 Rs2072472 Genetic Variants and Rheumatoid Arthritis Risk
| Gene | SNP | Model | Genotype | RA Patients | Control | OR (95% CI) | p | FDR Test |
|---|---|---|---|---|---|---|---|---|
| n (Freq) | n (Freq) | |||||||
| IL1R2 | rs2072472 | Allele | G | 234 (23.03%) | 195 (19.74%) | 1 | ||
| A | 782 (76.97%) | 793 (80.26%) | 1.22 (0.98–1.51) | 0.072 | 0.360 | |||
| Codominant | A/A | 296 (58.27%) | 323 (65.38%) | 1 | ||||
| A/G | 190 (37.40%) | 147 (29.76%) | 1.41 (1.08–1.84) | 0.011 | 0.275 | |||
| G/G | 22 (4.33%) | 24 (4.86%) | 1.00 (0.55–1.82) | 1 | 1.000 | |||
| Dominant | A/A | 296 (58.27%) | 323 (65.38%) | 1 | ||||
| A/G-G/G | 212 (41.73%) | 171 (34.62%) | 1.35 (1.05–1.75) | 0.021 | 0.350 | |||
| Recessive | A/G-A/A | 486 (95.67%) | 470 (95.14%) | 1 | ||||
| G/G | 22 (4.33%) | 24 (4.86%) | 0.89 (0.49–1.60) | 0.688 | 1.011 | |||
| Log-additive | - | - | - | 1.22 (0.98–1.51) | 0.073 | 0.608 |
Notes: OR (95% CI): Calculated by unconditional logistic regression adjusted by gender and age. p - value was calculated by two -sided χ2 test. Bold means statistical significance.
Abbreviations: RA, rheumatoid arthritis; IL1R2, interleukin-1 receptor 2; SNP, single-nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval; FDR, false discovery rate; freq, frequency.