Table 2.
Cumulative incidence and crude and adjusted hazard ratio for the primary and secondary endpoints in the general population and the atrioventricular block cohort
| Total number of events | 5-year cumulative incidence (95% CI) | 10-year cumulative incidence (95% CI) | 15-year cumulative incidence (95% CI) | Crude hazard ratio (95% CI) | Adjusted hazard ratioa (95% CI) | |
|---|---|---|---|---|---|---|
| Primary endpoint | ||||||
| General population (reference) | 219 | 1.4% (1.1–1.8%) | 3.3% (2.7–3.9%) | 5.9% (5.0–6.9%) | 1.0 | 1.0 |
| AVB cohort | 84 | 11.1% (8.6–14.1%) | 15.3% (12.2–19.1%) | 20.6% (16.5–25.6%) | 4.9 (3.7–6.3) | 3.8 (2.9–5.1) |
| Death from any cause | ||||||
| General population (reference) | 170 | 1.0% (0.8–1.3%) | 2.4% (1.9–2.9%) | 4.4% (3.7–5.3%) | 1.0 | 1.0 |
| AVB cohort | 46 | 5.7% (3.8–7.9%) | 8.6% (6.2–11.5%) | 11.4% (8.1–15.3%) | 3.3 (2.3–4.6) | 2.2 (1.5–3.2) |
| Heart failure hospitalization | ||||||
| General population (reference) | 51 | 0.3% (0.2–0.5%) | 0.7% (0.5–1.0%) | 1.3% (0.9–1.8%) | 1.0 | 1.0 |
| AVB cohort | 45 | 5.0% (3.3–7.2%) | 7.7% (5.4–10.4%) | 11.1% (7.9–14.8%) | 10.2 (6.6–15.7) | 8.6 (5.4–13.8) |
| Cardiovascular death | ||||||
| General population (reference) | 15 | 0.1% (0.04–0.2%) | 0.2% (0.1–0.4%) | 0.4% (0–0.8%) | 1.0 | 1.0 |
| AVB cohort | 19 | 2.4% (1.3–4.1%) | 3.5% (2.1–5.5%) | 4.6% (2.7–7.2%) | 12.7 (6.4–24.9) | 11.7 (5.7–23.3) |
| Ventricular tachyarrhythmia hospitalization | ||||||
| General population (reference) | 9 | 0.1% (0.03–0.2%) | 0.2% (0.07–0.3%) | 0.2% (0.1–0.4%) | 1.0 | 1.0 |
| AVB cohort | 13 | 1.9% (0.9–3.4%) | 2.8% (1.5–4.7%) | 3.6% (1.8–6.3%) | 14.4 (6.1–33.6) | 14.6 (5.8–36.5) |
AVB, atrioventricular block; CI, confidence interval.
a
Hazard ratios were adjusted for the matching variable sex and age and for the Charlson comorbidity index.