Table 2.
List of proteins highly expressed only in brain and testis, along with their UnitProt ID, gene name and the main biological process(es) associated (according to UnitProt). The biological processes associated with brain or testis function/development are bolded. CNS, central nervous system.
| UnitProt ID | gene name | protein name | biological processes |
|---|---|---|---|
| Q9H172 | ABCG4 | ATP-binding cassette sub-family G member 4 | cellular response to leukaemia inhibitory factor; cholesterol efflux; transmembrane transport |
| Q96M02 | C1ORF90 | (E2-independent) E3 ubiquitin-conjugating enzyme FATS | protein polyubiquitination and stabilization; regulation of centriole replication |
| Q13536 | C1ORF61 | protein CROC-4 (contingent replication of cDNA 4) | positive regulation of transcription by RNA polymerase II |
| Q5T035 | C9ORF129 | putative in characterized protein C9orf129 | — |
| P08912 | CHRM5 | muscarinic acetylcholine receptor M5 | chemical synaptic transport; dopamine transport; transmission of nerve impulse |
| Q12926 | ELAV2 | ELAV-like protein 2 | mRNA splicing, via spliceosome; regulation of transcription |
| Q49AJ0 | FAM135B | protein FAM135B | cellular lipid metabolic process |
| P43080 | GUCA1A | guanylyl cyclase-activating protein 1 | cellular response to calcium ion; signal transduction; visual perception |
| Q8NE63 | HIPK4 | homeodomain-interacting protein kinase 4 | histone phosphorylation; peptidyl-serine phosphorylation; protein autophosphorylation |
| A6NGN9 | IGLON5 | IgLON family member 5 | — |
| Q7Z553 | MDGA2 | MAM domain-containing glycosylphosphatidylinositol anchor protein 2 | spinal cord motor neuron differentiation |
| P60323 | NANOS3 | Nanos homolog 3 | germ cell development; multicellular organism development; regulation of cell cycle; spermatogenesis |
| O14594 | NCAN | neurocan core protein | cell adhesion; CNS development; chondroitin sulfate biosynthetic process |
| Q9NQ35 | NRIP3 | nuclear receptor-interacting protein 3 | — |
| Q9Y5K3 | PCYT1B | choline-phosphate cytidylyltransferase B | spermatogenesis; phosphatidylcholine biosynthetic process |
| P01213 | PDYN | proenkephalin-B | chemical synaptic transmission; G protein-coupled receptor signalling pathway; neuropeptide signalling pathway |
| Q96PV4 | PNMA5 | paraneoplastic antigen-like protein 5 | positive regulation of apoptotic process |
| Q8WY54 | PPM1E | protein phosphatase 1E | cellular response to drug; negative regulation of protein kinase activity |
| Q33E94 | RFX4 | transcription factor RFX4 | positive regulation of transcription by RNA polymerase II; cilium assembly |
| Q8N6R1 | SERP2 | stress-associated endoplasmic reticulum protein 2 | endoplasmic reticulum unfolded protein response; protein glycosylation; protein transport |
| Q6ZV89 | SH2D5 | SH2 domain-containing protein 5 | — |
| Q99963 | SH3GL3 | endophilin-A3 | CNS development; endocytosis; positive regulation of neuron differentiation |
| Q8TF17 | SH3TC2 | SH3 domain and tetratricopeptide repeat-containing protein 2 | peripheral nervous system myelin maintenance; regulation of intracellular protein transport |
| Q8N5S1 | SLC25A41 | solute carrier family 25 member 41 | — |
| Q99726 | SLC30A3 | zinc transporter 3 (ZnT-3) | regulation of sequestering zinc ion; response to zinc ion |
| O00570 | SOX1 | transcription factor SOX1 | cell differentiation; CNS development; chromatin organization; forebrain neuron development; neuron differentiation |
| Q16650 | TBR1 | T-box brain protein 1 | brain development; cell fate specification; regulation of axon guidance; regulation of transcription |
| O95409 | ZIC2 | zinc finger protein ZIC 2 | brain development; cell differentiation; positive regulation of transcription |
| O96T25 | ZIC5 | zinc finger protein ZIC 5 | cell differentiation; CNS development |