Table 4.
Main biological processes associated with the common proteins between human sperm and neuron. A list of all the associated biological processes are found in electronic supplementary material, table S2.
| GO term | description | count in gene set | FDR |
|---|---|---|---|
| development | |||
| GO:0032 502 | developmental process | 268/5401 | 4.08 × 10−9 |
| GO:0048869 | cellular developmental process | 175/3533 | 2.61 × 10−5 |
| GO:2000026 | regulation of multicellular organismal developmental | 90/1876 | 2.23 × 10−2 |
| GO:0021700 | developmental maturation | 17/216 | 3.35 × 10−2 |
| GO:0048639 | positive regulation of developmental growth | 14/165 | 3.93 × 10−2 |
| nervous system development | |||
| GO:0007399 | nervous system development | 181/2206 | 1.11 × 10−23 |
| GO:0022008 | neuron projection development | 68/616 | 6.03 × 10−13 |
| GO:0048666 | neuron development | 76/758 | 1.11 × 10−12 |
| GO:0061564 | axon development | 47/377 | 1.28 × 10−10 |
| GO:0007417 | central nervous system development | 60/861 | 3.14 × 10−5 |
| GO:0007420 | brain development | 47/650 | 1.80 × 10−4 |
| GO:0021695 | cerebellar cortex development | 7/49 | 3.63 × 10−2 |
| brain/neuron-associated processes | |||
| GO:0030182 | neuron differentiation | 86/940 | 1.64 × 10−12 |
| GO:0010975 | regulation of neuron projection development | 47/443 | 1.22 × 10−8 |
| GO:0007411 | axon guidance | 27/220 | 4.38 × 10−6 |
| GO:009893 | axonal transport | 9/43 | 1.50 × 10−3 |
| GO:0008038 | neuron recognition | 8/34 | 1.80 × 10−3 |
| GO:0001764 | neuron migration | 14/118 | 3.70 × 10−3 |
| GO:0007158 | neuron cell–cell adhesion | 5/14 | 7.50 × 10−3 |
| GO:0019228 | neuronal action potential | 6/31 | 2.17 × 10−2 |
| GO:0036514 | dopaminergic neuron axon guidance | 3/5 | 2.87 × 10−2 |
| exocytosis | |||
| GO:0017156 | calcium ion regulated exocytosis | 12/74 | 9.00 × 10−4 |
| GO:0016079 | synaptic vesicle exocytosis | 11/64 | 0.0011 |
| GO:0006904 | vesicle docking involved in exocytosis | 6/38 | 0.0439 |
| cell signalling | |||
| GO:0007267 | cell–cell signalling | 95/1073 | 4.86 × 10−13 |
| GO:0035637 | multicellular organismal signalling | 21/110 | 1.89 × 10−7 |
| GO:0023052 | signalling | 232/5108 | 1.10 × 10−4 |
| GO:0007215 | glutamate receptor signalling pathway | 9/43 | 1.50 × 10−3 |
| GO:1905114 | cell surface receptor signalling pathway | 30/383 | 1.80 × 10−3 |
| GO:1990034 | calcium-mediated signalling | 13/132 | 2.02 × 10−2 |
| GO:0035556 | intracellular signal transduction | 76/1528 | 2.17 × 10−2 |
| GO:0016055 | Wnt signalling pathway | 22/303 | 2.41 × 10−2 |