Figure 6.

Topological constraints of Nrp1 on binding with Spike protein trimer, bound to an ACE2 dimer. (a) ACE2 (yellow and lime, which also go into and through the membrane) and B⁰AT1 (light blue) 2:2 dimer complex at the bottom left. Shown is the Spike protein trimer (chains A, B, and C in blue, gray, and red, respectively) in the middle. Shown is Nrp1 (orange) at the bottom right of the figure. (b) Linear domain arrangement in the sequence of the Nrp1 receptor. (c) Estimated distance of C-terminus of the Nrp1 b2 domain to the membrane bilayer lipid headgroups in the different models with Nrp1 bound to chains A, B, and C. To see this figure in color, go online.